Pair Name	Parthenolide, Balsalazide
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BCL-xL	hsa598
	Down-regulation	Expression	CASP3	hsa836
	Down-regulation	Expression	CASP8	hsa841
	Down-regulation	Expression	CASP9	hsa842
	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Expression	CFLAR	hsa8837
	Down-regulation	Expression	MMP9	hsa4318
	Down-regulation	Activity	NFKB1	hsa4790
	Down-regulation	Phosphorylation	NFKBIA	hsa4792
	Up-regulation	Cleavage	PARP1	hsa142
	Down-regulation	Expression	PTGS2	hsa5743
	Up-regulation	Expression	TP53	hsa7157
	Down-regulation	Expression	VEGFA	hsa7422
In Vitro Model	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
Result	These results demonstrate that parthenolide potentiates the efficacy of balsalazide through synergistic inhibition of NF-κB activation and the combination of dual agents prevents colon carcinogenesis from chronic inflammation.